Healthy Living
Glutathione peroxidase in early and advanced Parkinson's disease
By Johannsen P; Velander G; Mai J; Thorling EB; Dupont E
Address: Department of Neurology, University Hospital, Aarhus Kommunehospital, Aarhus, DenmarkSource: J Neurol Neurosurg Psychiatry, 54(8):679-82 1991 Aug
Abstract
A defective antioxidant scavenging system plays a major role in one of the theories of the pathogenesis of Parkinson's disease. The aim of this study was to investigate whether there is a general difference in antioxidant activity between early and advanced cases of Parkinson's disease. Twenty five recently diagnosed patients, without any clinical fluctuations (group A), and 25 patients in a late phase of the disease with severe fluctuations in response to levodopa therapy (group B) were included in the study. Erythrocyte glutathione peroxidase was determined as a measure of antioxidant activity and significantly lower values were found in group B than in group A. Regression analyses in groups A and B showed significant correlation between glutathione peroxidase and duration of disease, but not between glutathione peroxidase and age of patients.
Publication Type: Journal Article ISSN 0022-3050